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Active Ingredient Production |Purification Process | Reaction Monitoring

More efficient reaction monitoring through online measurement methods, even for pro-cesses with spectroscopically inactive components

Online process control for precise reaction endpoint determination in a purification process

Online measurement methods enable reliable reaction tracking in real time

The analysis of substance mixtures using spectroscopic measurement methods is widely used in applications in the chemical and pharmaceutical industries, among others. The main advantages are the quantitative and qualitative determination of a defined substance or parameter with high precision and reproducibility and therefore optimum process control and process reliability. Conventional methods, such as gas chromotagraphy (GC), are problematic for some types of process where precise reaction endpoint determination is crucial, primarily due to the time delay in the measurement results. This is the case with purification processes, for example.

In order to meet the strict purity requirements of the chemical, food and pharmaceutical industries, an additional purification step is often carried out during the manufacturing process. A common purification process is the washing out of impurities from a system by adding a washing solution.

The Challenge

The detectability of an impurity in the production of an organic compound is to be confirmed by the presence of a precisely defined amount of this impurity in the washing solvent at the end of the washing process. The impurity to be removed cannot be detected by spectroscopic methods but only by gas chromatography. This presents a challenge for online process monitoring, especially for process measurements that require continuous analysis or very fast analysis times. In such cases, a chromatographic separation method represents a technical limitation.

 

 

Challenge

Use of online measurement technology for more efficient measurability in processes with a spectroscopically non-detectable reactant.

 

 

Scope of Application

Continuous monitoring and precise reaction endpoint determination in purification processes

 

 

Area of Application

  • Monitoring of purification processes
  • Production of active ingredients
  • Chemical and pharmaceutical Industry

 

Method

  • Process Analytical Technology (PAT)
  • NIR-Spectroscopy
  • Real-Time Measurement
  • Online Spectroscopy

Solution

  • NIR-Spectroscopy

  • Online/Inline

  • Real-Time Measurement

Benefits

  • Optimum process control through continuous real-time measurements
  • Compliant and safe production

The Application

During a purification process, it is necessary to extract a contaminant from the filter cake that forms during the washing process. The washing solvent after the reactor is monitored and the washing process is to be interrupted if it falls below a predefined threshold value.

Schematic representation of a filter cake wash

You want to know how this measurement task was solved the best possible way?

A more detailed description on how this application was realized using online measurement technology can be found in our detailed application report, which you can download from the info column at the top of the page.

Contact/Inquiry

Hellma USA Inc.
120 Terminal Drive
11803 Plainview, NY
United States

Phone: +1 5169 3908 88
info.us@hellma.com
www.hellmausa.com

Contact/Inquiry

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Complete Application Note

More efficient reaction monitoring through online measurement methods, even for processes with spectroscopically inactive components

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Datasheet Excalibur HD FCP

Excalibur HD FCP (Datasheet EN)

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